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KMID : 0359319900300030277
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Korean Journal of Veterinary Research
1990 Volume.30 No. 3 p.277 ~ p.281
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Antagonism of xylazine - induced hypotensive effect by yohimbine in rabbits
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Abstract
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Xylazine is commonly used for anesthesia in veterinary medicine and various adverse effects are developed. To examine if the severe hypotensive response associated with xylazine-induced anesthesia might be resulted from the stimulation of presynaptic alpha-2 adrenoceptors or the increase of vagal tone, effects of yohimbine, atropine and atropine with vagotomy on xylazine-induced severe and long-lasting hypotensive responses were investigated in rabbits.
The results were summarized as follows:
1) Intravenously injected xylazine(l㎎/㎏)-induced hypotensive responses were inhibited by yohimbine(p<0.001).
2) Intravenously injected xylazine(l㎎/㎏)-induced hyi~otensive responses were not changed by atropine.
3) Intravenously administered xylazine(l㎎/㎏)-induced hypotensive responses are not changed by atropine with vagotomy.
These results indicate that xylazine is thought to cause severe hypotensive response during anesthesia primarily by stimulating presynaptic alpha-2 adrenoceptors and other receptors or mechanisms may participate in the hgpotensive response of xylazine.
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